WhatcausesCrohnsdisease?克罗恩病是由什么引起的呢?
ThecauseofCrohnsdiseaseremainsuncertain.Althoughthereareanumberoftheories,nonehaveyetbeenproven.Whatisknownisthatfactorslikeapersonsgeneticmakeup,theenvironmentinwhichonelives,andanindividualsimmunesystemallplayaroleinthedevelopmentofthedisease,butexactlyhowthisoccursisnotclearlyunderstoodatthistime.However,manypotentialmechanismsforhowCrohnsdiseasemaydeveloparecurrentlyunderstudy.
克罗恩病的病因仍不确定。虽然有很多理论,但尚未得到证实。目前已知病因包括：基因构成、生活环境、免疫系统等都在疾病的发展中发挥作用，但如何通过何种机制起作用并不清楚。然而,许多潜在的致病机制正在进行研究。
Themostwidelyacceptedtheoryisthatapersonsimmunesystemabnormallyoverreactstosometypeofsubstanceinthegut(gastrointestinaltract),whichismostlikelythebacteriathatnormallyresideintheintestines,andthatthisoveractiveimmuneresponseissomehowtriggeredbyexposuretosomethinginthepersonsenvironment.Whyonepersondevelopsthistypeofimmuneresponsewhileanotherpersondoesnotisthoughttorelatetoanindividualsgeneticmakeuporgeneticsusceptibility;inotherwords,thepersonwhodevelopsCrohnsdiseasehasinheritedsometypeofdefectivegeneorgenesthatcausestheirimmunesystemtoreactinthisabnormalway.Thisactivationoftheimmunesystemleadstoaninfluxofinflammatorycellstotheintestine.InpatientswithCrohnsdisease,oncetheimmunesystemisactivated,itdoesnotproperlyshutitselfoff,whichresultsinthechronicinflammationthatischaracteristicofCrohnsdisease.ThisiswhymanyofthecurrenttreatmentsforCrohnsdiseasefocusonsuppressingthebodysoveractiveimmuneresponse.最被广泛接受的理论是,一个人的免疫系统对某种类型的异常反应过度的物质在肠道(胃肠道),这是最有可能的细菌通常存在于肠道,这过于活跃的免疫反应是由人的环境中接触的东西。为什么一个人发展这种类型的免疫反应,而另一个人不被认为与一个人的基因组成或遗传易感性;换句话说,开发克罗恩病的人继承了某种类型的有缺陷的基因或基因使他们的免疫系统反应在这个异常。这种免疫系统的激活会导致肠道炎症细胞的大量涌入。在克罗恩病的患者,一旦免疫系统被激活,它本身不正确地关闭了,结果在慢性炎症,是克罗恩病的特征。这就是为什么许多当前治疗克罗恩病的小儿白癜风怎样治疗西藏治疗白癜风的医院
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